Anti-Wrinkle Cosmetic Peptide Raw Powder Hexapeptide-11 CAS 161258-30-6

Hexapeptide-11 yog peptide tsim los ntawm 6 amino acids (H-Phe-Val-Ala-Pro-Phe-Pro-OH) ua ke los ntawm cov cuab yeej siv tshuaj tua kab mob. Tom qab tshuaj xyuas 22, 000 noob ntawm tib neeg genome, cov kws tshawb fawb pom tias Hexapeptide-11 tuaj yeem tswj tau rau 6 qhov tseem ceeb ntawm daim tawv nqaij, suav nrog cov proteins transmembrane, kev loj hlob, matrix proteins, kev loj hlob ntawm daim tawv nqaij lipid thiab cell shock / cell stress. , thiab kev tswj hwm cov tshuaj hormones.

Hexapeptide-11 upregulates tseem ceeb genes lub luag hauj lwm rau collagen ntau lawm thiab tseem ceeb extracellular matrix Cheebtsam xws li hyaluronic acid (HA) nyob rau hauv tib neeg dermal fibroblasts los txhawb kev tsim ntawm collagen thiab elastin, pab zawm daim tawv nqaij thiab tswj cov tawv nqaij kev ncaj ncees. Nws nce qhov kev qhia ntawm cov tshuaj antioxidant noob Nrf2, Keap1, NQO1, thiab TXNRD1 los tiv thaiv kev laus ntxov ntawm tes los ntawm oxidative kev nyuaj siab. Induction ntawm extracellular MMP-2 thiab MMP-9 enzyme kev ua haujlwm pab hauv kev kho qhov txhab. Yog li ntawd, Hexapeptide-11 tuaj yeem siv rau hauv kev tiv thaiv kev laus, kev tiv thaiv tawv nqaij, thiab cov khoom tu tus kheej.

Yav dhau los, Hexapeptide-11 feem ntau yog muab rho tawm los ntawm cov poov xab fermentation kua, tab sis tam sim no, nws yog feem ntau tsim los ntawm kev siv tshuaj synthesis, uas tsis yog tsuas yog nce nws cov txiaj ntsig, zoo, thiab purity tab sis kuj ua kom qhov tseeb ntawm nws cov qauv.

Cell Toxicity ntawm Hexapeptide-11
Txhawm rau kawm txog cytotoxicity ntawm Hexapeptide-11 ntawm tib neeg lub ntsws embryonic ntsws fibroblasts (IMR90) thiab tib neeg cov tawv nqaij fibroblasts (BJ), cov kws tshawb fawb tau coj ob hom fibroblasts hauv Hexapeptide -11 daws rau 24 thiab 48 teev, nrog maj mam nce. koob tshuaj, txhawm rau txheeb xyuas cell viability. Cov txiaj ntsig tau pom tias Hexapeptide-11 tsis muaj cytotoxicity tseem ceeb ntawm tib neeg fibroblasts (IMR90 thiab BJ). Tsis tas li ntawd, IMR90 tau pom tias muaj kev txhim kho me ntsis hauv kev ua haujlwm ntawm tes hauv qhov tsis tshua muaj siab ntawm Hexapeptide-11.

Kev cuam tshuam ntawm Hexapeptide-11 ntawm PN Genes
Ib txoj kev tshawb fawb Israeli pom tias kev poob qis ntawm cov protein homeostasis muaj kev cuam tshuam dav rau tib neeg kev laus. Txhawm rau tswj hwm cellular protein homeostasis, cov hlwb tau tsim ib qho modular protein homeostasis network (PN) los tswj cov haujlwm tseem ceeb ntawm cov protein, txo cov protein oxidative kev ntxhov siab los ntawm folding, degradation, thiab lwm yam, kom ntseeg tau tias kev tswj hwm ntawm cellular protein cov ntsiab lus.

Txhawm rau kawm txog kev cuam tshuam ntawm Hexapeptide-11 ntawm PN gene qhia, cov kws tshawb fawb tau tso IMR90 hlwb hauv 2% thiab 5% concentration Hexapeptide-11 cov kev daws rau 24 teev, tom qab ntawd siv cov tshuaj fluorescence quantitative PCR (Q-PCR). ) txhawm rau txheeb xyuas thiab txheeb xyuas cov txheeb ze mRNA qhia qib ntawm ntau cov noob.

Cov txiaj ntsig tau pom tias Hexapeptide-11 koob tshuaj-raws li ua rau kev qhia ntawm 20S thiab 19S proteasome subunit genes (7, 1, 2, 5, rpn6, rpn11); tswj cov noob caj noob ces cuam tshuam nrog amyotrophic lateral sclerosis (ALS) (ie, becn1, sqstm1, thiab hdac6, nrog rau cov ntaub so ntswg proteases ctsl thiab ctsd); thiab induced upregulation ntawm molecular chaperone noob (hsf1, hsp27, hsp70, hsp90, thiab clu) thiab cellular antioxidant noob (Nrf2, Keap1, NQO1, TXNRD1). Qhov kev sim qhia tias Hexapeptide-11 tuaj yeem tswj hwm qhov kev qhia ntawm qee cov noob hauv PN module raws li kev siv tshuaj, koom nrog kev tswj hwm ntawm cov protein homeostasis network.

Anti-aging Experiment of Hexapeptide-11
Txhawm rau kawm seb Hexapeptide-11 tuaj yeem tiv thaiv cov hlwb los ntawm oxidative stress-induced premature aging, researchers kho IMR90 cells with 300 mM H2O2 peb zaug (txhua rau 48 teev) los ua kom muaj kev ntxhov siab ua ntej ntxov ntxov (SIPS) signaling, ua rau IMR90 cell mus rau hnub nyoog. Ob pawg sib npaug tau kho nrog 5% Hexapeptide-11 lossis 300 mM H2O2 + 5% Hexapeptide-11. Tom qab ntawd, cov hlwb los ntawm plaub pawg sim tau tshuaj xyuas siv SA- -Gal staining. SA- -Gal staining tuaj yeem siv los txheeb xyuas qhov kev qhia ntawm -galactosidase kev ua haujlwm (hlwb yog xim xiav), uas yog qhov paub txog tus yam ntxwv ntawm cov hlwb senescent. Cov txiaj ntsig tau pom tias qhov ntau ntawm -galactosidase hauv pawg Hexapeptide-11 poob qis dua piv rau lwm pab pawg, qhia tias muaj kev tiv thaiv tseem ceeb ntawm Hexapeptide-11 tawm tsam H2O2- kho SIPS hauv hlwb.

Cov nyhuv ntawm Hexapeptide-11 ntawm daim tawv nqaij elasticity
Hauv kev soj ntsuam kev soj ntsuam kev ua tau zoo nrog 25 tus neeg tuaj yeem pab dawb, cov kws tshawb fawb tau siv lub toner uas muaj 2.8% Hexapeptide-11 thiab cov tshuaj placebo rau sab laug thiab sab xis ntawm cov neeg tuaj yeem ntsib ob zaug hauv ib hnub rau plaub lub lis piam. Daim tawv nqaij pib elasticity (Ue) thiab tag nrho deformation (Uf) tau soj ntsuam los ntsuas kev hloov pauv ntawm daim tawv nqaij elasticity hauv cov ntsiab lus.
Cov txiaj ntsig tau pom tias muaj kev txhim kho tseem ceeb hauv daim tawv nqaij pib elasticity (Ue) hauv pawg Hexapeptide-11, thaum tsis muaj kev hloov pauv loj hauv tag nrho deformation (Uf). Qhov kev sim ua pov thawj tias Hexapeptide-11 tuaj yeem ua kom tawv nqaij elasticity, ua kom tawv nqaij, thiab ua kom muaj kev tiv thaiv kev laus.

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